Background: Maximal voluntary isometric handgrip strength (MVIHS) is influenced by age, sex, and handedness.Aim: To assess the association of MVIHS with age, sex, and handedness in older adults. Material and methods: MVIHS was measured using a digital dynamometer in 60 men and 60 women aged 73 ± 6 years. Weight, height and handedness were also recorded. For analysis purposes, participants were divided into two age groups (65 to 70.9 years of age and ≥ 71 years). Results: A negative correlation was observed between age and MVIHS in the non-dominant (r = -0.65 and -0.59 in men and women, respectively) and dominant hands (r = -0.71 and -0.64 in men and women, respectively). When age and MVIHS were correlated in the group aged 65-70 years, a significant correlation was observed in the non-dominant (r = -045 and -0.61 in men and women, respectively) and dominant hands (r = -0.47 and -0.64 in men and women, respectively). In the group aged ≥ 71 years, a stronger correlation with age was also observed in the non-dominant (r = -0.92 and -0.90 in men and women, respectively) and dominant hands (r = -0.95 and -0.90 in men and women, respectively). MVIHS was 2.8 to 8.9% lower in the non-dominant than in the dominant hand in all age groups. MVIHS was lower in women than in men in both age groups. Conclusions: MVIHS declines with age (especially after 71 years of age), is higher in men than women, and higher in the dominant than the non-dominant hand.