Investigating the Effect of a High Fat Meal and Prolonged Sitting on Executive Function: A Pilot Study

Craig Paterson, Keeron J. Stone, Lee Stoner, Daniel P. Credeur, Aitor MartinezAguirre-Betolaza, Joesph Festa, Meghan A. Brown, John K. Parker, Simon Fryer

Research output: Contribution to conferencePoster

Abstract

Prolonged periods of sitting have been shown to reduce cerebral blood flow and autoregulation, which may subsequently impair executive function. Similarly, the consumption of a high-fat diet can negatively impact cerebral perfusion. However, whether prolonged sitting combined with a high fat meal additionally impairs both executive function and cerebral perfusion is unknown. PURPOSE: To investigate the effects of consuming a high-fat meal followed by 3 hours of prolonged sitting on executive function and cerebral perfusion. METHODS: Five young healthy males (Age: 22.8 ± 2.9 yrs; stature 177.7 ± 6.4 cm; mass 78.9 ± 14.3 kg), from a target of 18, were recruited. Following familiarisation, participants completed two randomised sessions of 3 hours of prolonged sitting following the consumption of a high-fat (HF) and low-fat (LF) meal. Each visit was separated by a minimum of 2 and maximum of 7 days. Participants completed a Stroop test (containing both congruent and incongruent trials) and trail-making test (TMT) both pre- and post- sitting period. The TMT consists of two parts, A and B. Continuous wave near-infrared spectroscopy (cw-NIRS) was used to measure cerebral perfusion at AF4 both before (baseline) and throughout each trial. Data was analyzed using two-way repeated measures analysis of variance. Alpha was set at P < 0.1 a priori for preliminary analyses. RESULTS: There were no significant differences between or within trials for completion time for Stroop and TMT part A. Completion time for TMT part B was significantly (p = 0.078, d = 2.2) faster in the low-fat condition compared to HF condition (16.4 ± 4 s vs. 21.6 ± 0.7 s). There were no significant differences in cerebral perfusion between or within groups (p = 0.201). CONCLUSIONS: These preliminary findings suggest that the consumption of a high-fat meal may negatively impact core executive functions measured by TMT Part B, namely working memory and task-switching ability. However, cerebral perfusion, as measured by cw-NIRS, failed to identify a mechanism. This may be a consequence of limited statistical power given the sample size, or uncertainties regarding the sensitivity of cw-NIRS when measuring cerebral perfusion
Original languageEnglish
Pages672
DOIs
Publication statusPublished - Jun 2019
Externally publishedYes

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    Paterson, C., Stone, K. J., Stoner, L., Credeur, D. P., MartinezAguirre-Betolaza, A., Festa, J., Brown, M. A., Parker, J. K., & Fryer, S. (2019). Investigating the Effect of a High Fat Meal and Prolonged Sitting on Executive Function: A Pilot Study. 672. https://doi.org/10.1249/01.mss.0000562513.68051.35