Structural proteins of Helicoverpa armigera densovirus 2 enhance transcription of viral genes through transactivation

Pengjun Xu, He Yuan, Xianming Yang, Robert I. Graham, Kaiyu Liu, Kongming Wu

Research output: Contribution to journalJournal Article

1 Citation (Scopus)


© 2017, Springer-Verlag Wien. Herein, we report the identification of putative promoters for the non-structural proteins (NS) and capsid structural proteins (VP) of Helicoverpa armigera densovirus (HaDV2) as well as a potential mechanism for how these promoters might be regulated. For the first time, we report that VP is able to transactivate the VP promoter and, to a lesser degree, the NS promoter in densoviruses. In addition to this, another promoter-like sequence designated P2, when co-transfected with the VP gene, enhanced luciferase activity by approximately 35 times compared to a control. This suggests that there are two promoters for VP in HaDV2 and that the VP of parvoviruses might play a more important role in viral transcription than previously appreciated.
Original languageEnglish
Pages (from-to)1745-1750
Number of pages6
JournalArchives of Virology
Issue number6
Publication statusPublished - 1 Jun 2017
Externally publishedYes


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