© 2017, Springer-Verlag Wien. Herein, we report the identification of putative promoters for the non-structural proteins (NS) and capsid structural proteins (VP) of Helicoverpa armigera densovirus (HaDV2) as well as a potential mechanism for how these promoters might be regulated. For the first time, we report that VP is able to transactivate the VP promoter and, to a lesser degree, the NS promoter in densoviruses. In addition to this, another promoter-like sequence designated P2, when co-transfected with the VP gene, enhanced luciferase activity by approximately 35 times compared to a control. This suggests that there are two promoters for VP in HaDV2 and that the VP of parvoviruses might play a more important role in viral transcription than previously appreciated.
Xu, P., Yuan, H., Yang, X., Graham, R. I., Liu, K., & Wu, K. (2017). Structural proteins of Helicoverpa armigera densovirus 2 enhance transcription of viral genes through transactivation. Archives of Virology, 162(6), 1745-1750. https://doi.org/10.1007/s00705-017-3253-0